InspiWaveTM

Clinical Evidence

We have completed the R&D phase. In a controlled R&D environment, we have the capability of the device to measure dead space, effective lung volume, pulmonary blood flow, and lung inhomogeneity on a wide range of subjects: artificial lung, volunteers,  patients in operating theatres, ICUs, and lung function labs, COPD outpatients, and piglets.

The results of these validation tests have been reported in 10 high-ranking peer reviewed scientific publications. More details of our clinical evidence and the list of our publications can be found here.

  1. Assessment of lung function in patients with COPD using the Inspired Sinewave Technique
  2. Validating the inspired sinewave technique to measure the volume of the “baby lung” in a porcine lung injury model
  3. The Inspired Sinewave Technique A Comparison Study With Body Plethysmography In Healthy Volunteers
  4. The inspired sine-wave technique – A novel method to measure lung volume and ventilatory heterogeneity
  5. Simulation-based optimisation to quantify heterogeneity of specific ventilation and perfusion in the lung by the Inspired Sinewave Test
  6. Measurement of Heart and Lung Function in Neurocritical Care Using the Inspired Sinewave Technique
The Bland – Altman plot analysis showed strong agreement between InspiWaveTM and Body Plethysmograph , in measuring effective lung volume
strong agreement (92.5 %) between InspiWaveTM and intermittent measurements by the “gold standard” – thermodilution
strong correlations between InspiWaveTM (IST) and SF6/CT in measuring lung volume, with R2 of 0.87 and 0.92 respectively.
InspiWaveTM‘s index of lung inhomogeneity was a superior predictor of COPD severity vs FEV 1%, and classification vs standard symptom severity questionnaires.